ABSTRACT
Background & objectives: In acute pancreatitis (AP) gut barrier dysfunction is considered as an important predisposing factor leading to increased intestinal permeability (IP). In this study a pooled analysis of data published in our previous four studies on various aspects of gut permeability and endotoxaemia in patients with AP was attempted to find an association between increased IP and severity of disease and associated complications. Methods: This study was a pooled analysis of data of four previously published prospective studies on AP. Gut permeability, assessed by lactulose/mannitol excretion in urine and endotoxin core antibodies type IgG and IgM (EndoCab IgG and IgM) were measured on days zero and seven (D0 and D7) of admission. All patients received standard treatment of AP. We studied whether IgG and IgM anti-endotoxin titres and lactulose-mannitol ratio (LMR) at admission and D7 were associated with organ failure, infection and mortality. Results: The titres of anti-endotoxin IgG and IgM were lower in all patients of AP (n=204), both in mild AP (n=24) and severe AP (n=180) in the first week, compared to controls (n=15). There was no significant difference in serum IgG and IgM anti-endotoxin levels and LMR at baseline and at D7 among patients with organ failure, infection and mortality. Interpretation & conclusions: Our findings showed that serum IgG and IgM anti-endotoxin titres and LMR at admission and at day 7 were not associated with organ failure, infection, and death of patients with AP.
Subject(s)
Adult , Aged , Breath Tests , Female , Helicobacter Infections/epidemiology , Helicobacter pylori , Humans , India/epidemiology , Male , Middle Aged , PrevalenceABSTRACT
An epidemiological study on interrelationship between dental caries and sugar consumption conducted on 1265 children in the age of 5-15 years revealed a positive association of dental caries experience with total sugar exposures, between meal sugar exposures and at meal sugar exposures. As the total increased from 3 to 4 in a day, a corresponding jump of 1 deft+DMFT and 2 defs+DMFS was noted, which was clinically and statistically significant. It was deduced that total sugar exposures per day should be limited to 3, out of which two should be at meal time and one between meals.
Subject(s)
Adolescent , Child , DMF Index , Dental Caries/epidemiology , Diet, Cariogenic , Feeding Behavior , Female , Humans , India/epidemiology , Male , Prevalence , Rural Population , Socioeconomic Factors , Sucrose/adverse effects , Urban PopulationABSTRACT
Dental caries was recorded using WHO index (1983) and Moller's index (1966) in 1265 children in the age group of 5, 8, 11 and 15 years to determine the conversion and correlation figures, so as to facilitate cross comparison and quick appraisal where either of the systems have been used in epidemiological studies. The results revealed that dental caries was recorded higher with Moller's index as compared to the WHO index; on an average the difference was fourteen percent in point prevalence, one deft + DMFT and one and a half defs + DMFS.